Dan Ziegler Selected Research

Thioctic Acid (Lipoic Acid)

4/2022	Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations.
1/2022	The Role of Biofactors in Diabetic Microvascular Complications.
1/2021	Double-blind, randomized, placebo-controlled crossover trial of alpha-lipoic acid for the treatment of fibromyalgia pain: the IMPALA trial.
3/2017	Innovations in the Management of Musculoskeletal Pain With Alpha-Lipoic Acid (IMPALA Trial): Study protocol for a Double-Blind, Randomized, Placebo-Controlled Crossover Trial of Alpha-Lipoic Acid for the Treatment of Fibromyalgia Pain.
3/2016	Predictors of improvement and progression of diabetic polyneuropathy following treatment with α-lipoic acid for 4 years in the NATHAN 1 trial.
1/2015	Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading.
12/2014	Efficacy of α-lipoic acid in diabetic neuropathy.
9/2011	Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial.
11/2006	Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial.
1/2004	Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review.

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Dan Ziegler Research Topics

Disease

34	Diabetic Neuropathies (Diabetic Neuropathy) 06/2022 - 01/2002
27	Type 2 Diabetes Mellitus (MODY) 02/2022 - 02/2009
24	Polyneuropathies (Polyneuropathy) 02/2022 - 01/2004
20	Neuralgia (Stump Neuralgia) 06/2022 - 01/2007
20	Pain (Aches) 06/2022 - 03/2003
11	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022 - 09/2006
10	Inflammation (Inflammations) 01/2022 - 08/2009
9	Insulin Resistance 01/2022 - 01/2015
8	Peripheral Nervous System Diseases (PNS Diseases) 06/2022 - 08/2013
8	Glucose Intolerance 05/2015 - 03/2008
6	Obesity 01/2022 - 01/2018
6	Diabetes Mellitus 03/2019 - 07/2011
6	Hypertension (High Blood Pressure) 10/2017 - 07/2004
4	Diabetes Complications 01/2020 - 07/2006
4	Dyslipidemias (Dyslipidemia) 10/2017 - 07/2004
3	Hyperalgesia 01/2022 - 06/2012
3	Erectile Dysfunction 01/2022 - 09/2006
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 03/2008
3	Abdominal Obesity 01/2019 - 01/2014
3	Stroke (Strokes) 01/2015 - 07/2004
3	Myocardial Infarction 01/2015 - 07/2009
2	Hyperglycemia 01/2022 - 01/2018
2	Ulcer 02/2021 - 08/2009
2	Chronic Pain 01/2021 - 07/2015
2	Virus Diseases (Viral Diseases) 01/2021 - 07/2015
2	Fibromyalgia (Fibrositis) 01/2021 - 03/2017
2	Low Back Pain (Lumbago) 01/2021 - 07/2015
2	Neuroblastoma 01/2021 - 11/2018
2	Postoperative Pain 01/2021 - 07/2015
2	Postherpetic Neuralgia 01/2021 - 07/2015
2	Prediabetic State (Prediabetes) 01/2021 - 03/2009
2	Painful Neuropathy 01/2020 - 01/2015
2	Foot Ulcer 12/2014 - 08/2009
1	Overweight 01/2022
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2022
1	Blindness (Hysterical Blindness) 01/2022
1	Demyelinating Diseases (Demyelinating Disease) 12/2021
1	Arthritis (Polyarthritis) 01/2021
1	Osteoarthritis 01/2021

Drug/Important Bio-Agent (IBA)

23	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 07/2004
17	Biomarkers (Surrogate Marker)IBA 01/2022 - 09/2004
13	Analgesics (Analgesic Drugs)IBA 04/2022 - 11/2006
11	Thioctic Acid (Lipoic Acid)IBA 04/2022 - 03/2003
9	Duloxetine Hydrochloride (Cymbalta)FDA Link 10/2014 - 11/2006
7	AntioxidantsIBA 01/2021 - 03/2003
7	Pregabalin (Lyrica)FDA Link 10/2015 - 11/2006
6	Anticonvulsants (Antiepileptic Drugs)IBA 04/2022 - 05/2008
5	Opioid Analgesics (Opioids)IBA 04/2022 - 09/2006
5	benphothiamine (benfotiamine)IBA 04/2022 - 11/2012
5	Pharmaceutical PreparationsIBA 12/2016 - 01/2002
4	Insulin (Novolin)FDA Link 01/2022 - 03/2007
4	LipidsIBA 01/2021 - 01/2015
4	CytokinesIBA 01/2019 - 04/2009
4	ChemokinesIBA 01/2019 - 04/2009
4	InterleukinsIBA 01/2017 - 04/2009
3	Antidepressive Agents (Antidepressants)IBA 04/2022 - 01/2018
3	C-Reactive ProteinIBA 01/2022 - 04/2009
3	Superoxides (Superoxide)IBA 01/2018 - 01/2004
3	ActoveginIBA 07/2017 - 08/2009
3	Interleukin-6 (Interleukin 6)IBA 04/2016 - 11/2013
3	NAD (NADH)IBA 01/2015 - 08/2013
3	CholesterolIBA 01/2015 - 02/2008
3	Gabapentin (Neurontin)FDA LinkGeneric 10/2014 - 05/2008
3	Free RadicalsIBA 01/2006 - 01/2004
2	Proteins (Proteins, Gene)FDA Link 12/2021 - 01/2019
2	Pyruvaldehyde (Methylglyoxal)IBA 01/2021 - 06/2012
2	ElementsIBA 01/2021 - 07/2015
2	Sodium Channels (Sodium Channel)IBA 01/2020 - 01/2019
2	EnzymesIBA 01/2020 - 01/2017
2	Voltage-Gated Sodium ChannelsIBA 01/2019 - 10/2014
2	Indicators and Reagents (Reagents)IBA 01/2018 - 01/2017
2	Triglycerides (Triacylglycerol)IBA 01/2018 - 01/2010
2	Glucagon (Glukagon)FDA Link 01/2018 - 04/2016
2	Superoxide DismutaseIBA 11/2017 - 07/2015
2	AdiponectinIBA 01/2017 - 04/2016
2	Calcium Channels (Calcium Channel)IBA 10/2015 - 05/2008
2	Lacosamide FDA Link 04/2010 - 12/2007
2	Acute-Phase Proteins (Acute-Phase Protein)IBA 08/2009 - 04/2009
1	Ion Channels (Ion Channel)IBA 06/2022
1	Capsaicin (Zostrix)FDA Link 04/2022
1	hydroxide ionIBA 01/2022
1	25-hydroxyvitamin DIBA 01/2022
1	Messenger RNA (mRNA)IBA 12/2021
1	Myelin P0 Protein (Myelin Protein Zero)IBA 12/2021
1	Nonesterified Fatty Acids (NEFA)IBA 01/2021
1	Environmental Pollutants (Pollutants, Environmental)IBA 01/2021
1	Phosphatidylcholines (Phosphatidylcholine)IBA 01/2021
1	Lysophosphatidylcholines (Lysophosphatidylcholine)IBA 01/2021
1	MagnesiumIBA 01/2021
1	MicroRNAs (MicroRNA)IBA 01/2021
1	Neuroprotective AgentsIBA 01/2021
1	SphingomyelinsIBA 01/2021
1	Persistent Organic PollutantsIBA 01/2021
1	Air Pollutants (Pollutants, Air)IBA 12/2020

Therapy/Procedure

8	Drug Therapy (Chemotherapy) 04/2022 - 09/2014
6	Therapeutics 01/2022 - 09/2006
6	Glycemic Control 01/2022 - 09/2006
3	Surgical Amputation (Amputations) 01/2022 - 12/2014
2	Secondary Prevention 01/2021 - 07/2015
1	Pain Management 04/2022